This is a particular set of broken windows that is long overdue fixing.
I think though it depends on where you are sitting as to whether your Panel question is topical or not.
If you are using a Panel to administer a host then you are driving a web application. This is not system administration within the meaning of Server Fault and your question is not topical.
If you are providing Panel systems to end users then conceivably you might have a panel related question about it's installation/configuration etc. which may be topical on SF.
Having said that I can't recall seeing a question that falls into the latter category so yeah burninate them
On a practical level perhaps we should have a canonical Q&A which tells people why we consider these questions to be off topic which also points people to the relevant support channels. This we can then use as a close target and pile them up as a warning to others
